癌症細胞的生長速度往往都高於一般細胞，因此癌細胞對於細胞代謝的需求也會增加許多，為了能夠滿足癌細胞所需的能量代謝，癌細胞通常會改變其代謝的方式與分子調控，以確保癌細胞能得到足夠的ATP進而生長與存活。而此種癌細胞與正常細胞能量代謝上的差異，更可以在癌症標靶治療上，提供一個有力的應用，近年來亦有許多研究已證實。因此本課程將會提供完整的有關癌症能量代謝之基礎理論與分子機轉，同時也會探討能量代謝與癌細胞的生長，死亡，侵略，與轉移，並進一步討論其於臨床癌症治療上的應用，使同學能對於癌症能量代謝有更多的認識，並利用這些知識於實驗研究上。
Cancer cells exhibit highly proliferate due to consume additional nutrients and distract those nutrients into macromolecular synthesis pathways in comparison with normal cells. In order to support cancer cells growth and survival, metabolic pathways need to rearrange to insure the sufficient ATP production. The alteration of metabolic pathways in all cancer cells displays a new window for therapeutic targets. Therefore, the purpose of this class is to provide knowledge for molecular basis of cancer cell metabolism and how metabolism to regulate cancer cell survival, death, invasion, and metastasis. Moreover, cancer cell metabolism pathways potentially become therapeutic targets will be further discussed in the class.
先修科目Prerequisites
無
No required
教學方式Teaching Methods
講課
Lecturing
小組討論、腦力激盪(如案例討論、電影欣賞等)
Group discussion, Brain storming, e.g., Case study, Event discussion, Movie review
學生上台報告、角色演練
Oral presentation, Role playing
評量方式Assessment
期末報告
Final report
出席狀況
Class attendance
Final report
參考書目Reference
1.Cancer as a Metabolic Disease: on the Origin, Management, and Prevention of Cancer-by Tomas N. Seyfried(2012)
2.Mitochondria and Cancer - by Keshav K. sungh et al.(2009)
3.Cancer Cell Metabolism and Cancer Treatment-by Aurel Lupulescu(2001)
4.SCI papers.
教學進度Course Schedule
2022/09/12 課程簡介
Introduction
陳雅惠(Ya-Huey Chen) 2022/09/19 癌症代謝之基礎
Fundamental of cancer cell metabolism
陳雅惠(Ya-Huey Chen) 2022/09/26 癌症代謝之調控因子
Controlling factors of cancer cell metabolism
陳雅惠(Ya-Huey Chen) 2022/10/03 正常與癌細胞之能量學
Energetics of normal cell and cancer cells
陳雅惠(Ya-Huey Chen) 2022/10/10 國慶連假
Double Tenth National Day
陳雅惠(Ya-Huey Chen) 2022/10/17 粒線體(mitochondria)和癌症
Mitochondria and cancer
陳雅惠(Ya-Huey Chen) 2022/10/24 粒線體之呼吸及分化作用
Mitochondria respiration and differentiation
陳雅惠(Ya-Huey Chen) 2022/10/31 癌症代謝之Waburg效應
Warburg effect in cancer metabolism
陳雅惠(Ya-Huey Chen) 2022/11/07 期中考
Middle examination
陳雅惠(Ya-Huey Chen) 2022/11/14 脂酯的轉換
Lipogenic switch
陳雅惠(Ya-Huey Chen) 2022/11/21 癌症代謝，細胞週期，與細胞死亡
Cancer cell metabolism, cell cycle, and cell death
陳雅惠(Ya-Huey Chen) 2022/11/28 癌症代謝與轉移
Cancer metabolism and cancer metastasis
陳雅惠(Ya-Huey Chen) 2022/12/05 前列腺癌與其它癌症中之檸檬酸代謝
Citrate metabolism in prostate and other cancers
陳雅惠(Ya-Huey Chen) 2022/12/12 腫瘤細胞中與代謝相關之遺傳與蛋白質譜分析
Integration of genetics, proteomic and metabolic approaches in tumor cell metabolisms
陳雅惠(Ya-Huey Chen) 2022/12/19 能量生成之路徑與p53
Energy generating pathways and tumor suppressor p53
陳雅惠(Ya-Huey Chen) 2022/12/26 粒線體可為腫瘤抑制者
Mitochondria tumor supperssors
陳雅惠(Ya-Huey Chen) 2023/01/02 參考文獻之討論與報告
Literatures discussion-II
陳雅惠(Ya-Huey Chen) 2023/01/09 期末考
Final examination
陳雅惠(Ya-Huey Chen)