癌症細胞的生長速度往往都高於一般細胞，因此癌細胞對於細胞代謝的需求也會增加許多，為了能夠滿足癌細胞所需的能量代謝，癌細胞通常會改變其代謝的方式與分子調控，以確保癌細胞能得到足夠的ATP進而生長與存活。而此種癌細胞與正常細胞能量代謝上的差異，更可以在癌症標靶治療上，提供一個有力的應用，近年來亦有許多研究已證實。因此本課程將會提供完整的有關癌症能量代謝之基礎理論與分子機轉，同時也會探討能量代謝與癌細胞的生長，死亡，侵略，與轉移，並進一步討論其於臨床癌症治療上的應用，使同學能對於癌症能量代謝有更多的認識，並利用這些知識於實驗研究上。
Cancer cells exhibit highly proliferate due to consume additional nutrients and distract those nutrients into macromolecular synthesis pathways in comparison with normal cells. In order to support cancer cells growth and survival, metabolic pathways need to rearrange to insure the sufficient ATP production. The alteration of metabolic pathways in all cancer cells displays a new window for therapeutic targets. Therefore, the purpose of this class is to provide knowledge for molecular basis of cancer cell metabolism and how metabolism to regulate cancer cell survival, death, invasion, and metastasis. Moreover, cancer cell metabolism pathways potentially become therapeutic targets will be further discussed in the class.
先修科目Prerequisites
無
No
教學方式Teaching Methods
評量方式Assessment
Attending the class and the attitude in the class (10%)
Final report (45%)
Presentation and discussion in the class (45%)
參考書目Reference
1. Cancer as a Metabolic Disease: on the Origin, Management, and Prevention of Cancer–by Thomas N. Seyfried (2012)
2. Mitochondria and Cancer –by Keshav K. Singh et al. (2009)
3. Cancer Cell Metabolism and Cancer Treatment-by Aurel Lupulescu (2001)
4. SCI papers.
教學進度Course Schedule
2022/02/21 課程簡介
腫瘤細胞之代謝管理
Introduction
Metabolic management of cancer
陳雅惠(Ya-Huey Chen) 2022/02/28 228和平紀念日
228 Peace Memorial Day
陳雅惠(Ya-Huey Chen) 2022/03/07 腫瘤細胞之能量代謝與細胞凋亡
Integration of energy metabolism and control of apoptosis in tumor cell
陳雅惠(Ya-Huey Chen) 2022/03/14 細胞生長異常與Telomerase活性之相關
Linking abnormalities in growth control, telomerase activity
陳雅惠(Ya-Huey Chen) 2022/03/21 血癌之癌細胞代謝
Metabolism in Hematology
陳雅惠(Ya-Huey Chen) 2022/03/28 癌細胞代謝與腫瘤血管新生
Cancer metabolism and tumor angiogenesis
陳雅惠(Ya-Huey Chen) 2022/04/04 癌細胞代謝與抗藥性
Cancer metabolism and drug resistance
陳雅惠(Ya-Huey Chen) 2022/04/11 代謝的活化與抗癌藥之去毒性
Metabolic activation and detoxification of cancer drugs
陳雅惠(Ya-Huey Chen) 2022/04/18 期中考
Middle examination
陳雅惠(Ya-Huey Chen) 2022/04/25 利用Warburg效應發展抗癌藥物
Reversing the Warburg effect: metabolic regulation as a novel cancer therapy
陳雅惠(Ya-Huey Chen) 2022/05/02 粒線體之癌症標靶治療
Mitochondria as targets for cancer therapy
陳雅惠(Ya-Huey Chen) 2022/05/09 粒線體之奈米技術與癌症治療
Mitochondria nanotechnology for cancer therapy
陳雅惠(Ya-Huey Chen) 2022/05/16 癌細胞代謝，營養與飲食
Cancer cell metabolism, nutrition and diet
陳雅惠(Ya-Huey Chen) 2022/05/23 癌症預防中之癌症代謝的角色
Role of cancer metabolism in cancer prevention
陳雅惠(Ya-Huey Chen) 2022/05/30 癌症代謝與新抗癌藥物之發展
Cancer metabolism and development novel anticancer drugs
陳雅惠(Ya-Huey Chen) 2022/06/06 參考文獻之討論與報告(I)
Literatures discussion(I)
陳雅惠(Ya-Huey Chen) 2022/06/13 參考文獻之討論與報告(II)
Literatures discussion(II)
陳雅惠(Ya-Huey Chen) 2022/06/20 期末考
Final examination
陳雅惠(Ya-Huey Chen)