Targeted therapies using specific inhibitors against cell surface markers and signal transduction molecules have been viewed as promising strategies for cancer therapy. However, the development of drug resistance remains the major issue limiting their therapeutic efficacy. This lecture will (1) introduce major cellular signaling pathways involved in cancer development to identify potential targets for therapeutic interventions, (2) describe how targeted therapies may work in the treatment of various tumors, and (3) assess the current knowledge of the molecular mechanisms conferring to intrinsic/acquired resistance of targeted therapies.
Oral presentation, Role playing
1.Targeted Cancer Therapy/edited by Razelle Kurzrock, Maurie Markman/Humana Press, Totowa, NJ/2008
2.Targeted Therapies in Cancer Myth or Reality? /Colotta, Francesco and Mantovani, Alberto./SpringerLink/ 2008
3.Targeted Therapies in Oncology-Guiseppe Giacone and Jean-Charles Soria