1. Chromatin structure and gene expression 2. The history of epigenetics 3. Chromatin modifier enzymes 4. DNA methylation and demethylation 5. Epigenetic control by Histone code 6. Signal transduction in epigenetics 7. Diagnostic and therapeutic applications of epigenetics 8. Cross-talk between aging and cancer: the epigenetic language
教學目標Course Objectives
腫瘤的形成受遺傳學(genetics)及外遺傳學(epigenetics)修飾的影響。在不涉及基因核酸序列改變之下，外遺傳調控可藉由影響DNA及染色體上組蛋白(histone)之修飾達到控制基因表現的作用。致癌基因 (Oncogene) 與抑癌基因 (tumor suppressor gene)表現的外遺傳調控失常為細胞癌化的主要關鍵。經由本課程之選修，期望研究生得以瞭解各種癌症外遺傳調控作用及相關抗癌藥物的發展，並培養研究生思考、分析、組織及表達之能力，為研究論文奠定基石。
Epigenetics refers to heritable changes in gene expression that occur without alteration in DNA sequence. There are two primary and interconnected epigenetic mechanisms - DNA methylation and covalent modification of histones. The dysregulation of oncogene or tumor supressor gene at epigenetical level is crucial for tumorigenesis. This lecture will describe the epigenetic regulations of gene expression and introduce major cellular signaling pathways involved in cancer epigenetics.
先修科目Prerequisites
教學方式Teaching Methods
講課
Lecturing
學生創新、創意活動
Innovation, creative activities
學生上台報告、角色演練
Oral presentation, Role playing
評量方式Assessment
個人上台報告
Oral Report
出席狀況
Class attendance
依學生報告之內容以及問題之回答各佔總分之70%及30%而評分。