要求學生充分熟悉 1. 生物分子之種類、物理化學性質及其生物功能；2. 了解生化原理，包括:結構-功能相關性，化學活性，酵素動力學與平衡、熱力學，生物膜結構及功能，能量代謝路徑、整合及調節；3. 生物分子之新陳代謝及其調控。
Biochemistry is essential to the study and practice of medicine. The intention of the course is for students to (1) know the composition, structure, and function of the major classes of biological molecules. (2) understand the biochemical principles, including: structure-function correlation; chemical reactivity, kinetics and equilibrium; thermodynamics, membrane structure and function; metabolic energy pathways, integration and regulation. (3) understand how improper regulation of these biochemical processes can lead to human disease.
先修科目Prerequisites
生物學、普通化學、有機化學
Biology, General Chemistry, Organic Chemistry
教學方式Teaching Methods
非同步教學(主要提供線上影音教材，透過線上教學平台進行作業及討論)
Asynchronous Online Learning
講課
Lecturing
習題練習、書面報告
Exercise, Written report
評量方式Assessment
期中筆試
Midterm exam
期末筆試
Final exam
出席狀況
Class attendance
課堂參與與表現
Class involvement
參考書目Reference
教科書：Reginald H. Garrett and Charles M. Grisham (2023) Biochemistry, 7th ed. 參考書： 1. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. (2023) Biochemistry, 10th ed. 2. Victor W Rodwell, David A. Bender, Kathleen M. Botham, Peter J. Kennelly, P. Anthony Weil (2023) Harper’s Illustrated Biochemistry, 32nd ed. 3. David L. Nelson and Michael M. Cox. (2021) Lehninger Principles of Biochemistry, 8th ed. 4. Denise R. Ferrier. (2021) Lippincott’s Illustrated Reviews: Biochemistry, 8th ed. 5. Mary K. Campbell and Shawn O. Farrell. (2012) Biochemistry, 7th ed. 6. Christopher K. Mathews, K.E.Van Holed, Dean R. Appling, and Spencer J. Anthony-Cahill (2013) Biochemistry, 4th ed
教學進度Course Schedule
2025/09/10 脂質 [實體]
Lipids
林瑜姿(Lin,Yu-Tzu) 2025/09/17 脂肪酸代謝 [線上非同步]
Fatty Acid Catabolism
林瑜姿(Lin,Yu-Tzu) 2025/09/24 脂肪酸代謝與脂質生合成 [線上非同步]
Fatty Acid Catabolism and Lipids Biosynthesis
林瑜姿(Lin,Yu-Tzu) 2025/10/01 脂質生合成 [線上非同步]
Lipids Biosynthesis
林瑜姿(Lin,Yu-Tzu) 2025/10/08 膽固醇代謝 [線上非同步]
Cholesterol Metabolism
林瑜姿(Lin,Yu-Tzu) 2025/10/15 胺基酸代謝(I) [線上非同步]
Nitrogen Acquisition and Amino Acid Metabolism(I)
林瑜姿(Lin,Yu-Tzu) 2025/10/22 胺基酸代謝(II) [線上非同步]
Nitrogen Acquisition and Amino Acid Metabolism(II)
林瑜姿(Lin,Yu-Tzu) 2025/10/29 血基質代謝與胺基酸轉變成特殊產物 [實體]
Metabolism of Heme and Conversion of Amino Acids to Specialized Products
林瑜姿(Lin,Yu-Tzu) 2025/11/05 期中考 [實體]
Mid-Term Examination
林瑜姿(Lin,Yu-Tzu) 2025/11/12 核苷酸的合成及降解(I) [實體]
Synthesis and Degradation of Nucleotides(I)
林瑜姿(Lin,Yu-Tzu) 2025/11/19 核苷酸的合成及降解(II) [線上非同步]
Synthesis and Degradation of Nucleotides(II)
林瑜姿(Lin,Yu-Tzu) 2025/11/26 代謝整合與器官的專一性(I) [線上非同步]
Metabolic Integration and Organ Specialization(I)
林瑜姿(Lin,Yu-Tzu) 2025/12/03 代謝整合與器官的專一性(II) [線上非同步]
Metabolic Integration and Organ Specialization(II)
林瑜姿(Lin,Yu-Tzu) 2025/12/10 膜與膜的轉運(I) [線上非同步]
Membranes and Membrane transport(I)
林瑜姿(Lin,Yu-Tzu) 2025/12/17 膜與膜的轉運(II) [實體]
Membranes and Membrane transport(II)
林瑜姿(Lin,Yu-Tzu) 2025/12/24 期末考 [實體]
Final Examination
林瑜姿(Lin,Yu-Tzu) 2025/12/31 細胞外信息的接收與傳遞(I) [線上非同步]
The Reception and Transmission of extracellular(I)
林瑜姿(Lin,Yu-Tzu) 2026/01/07 細胞外信息的接收與傳遞(II) [線上非同步]
The Reception and Transmission of extracellular(II)
林瑜姿(Lin,Yu-Tzu)