要求學生充分熟悉: 1. 生物分子之種類、物理化學性質及其生物功能 2. 了解生化原理,包括:結構-功能相關性,化學活性,酵素動力學與平衡、熱力學,生物膜結構及功能,能量代謝路徑、代謝整合及調節 3. 生物分子之新陳代謝及其調控異常所導致的疾病。
The intention of the course for students is to 1. know the composition, structure, and function of the major classes of biological molecules 2. understand the biochemical principles, including: structure-function correlation, chemical reactivity, enzyme kinetics and equilibrium, thermodynamics, membrane structure and function, metabolic pathways of energy, and integration and regulation of metabolism 3. understand how improper regulation of these biochemical processes can lead to human diseases.
先修科目Prerequisites
生物學、普通化學
Biology, General Chemistry
教學方式Teaching Methods
講課
Lecturing
評量方式Assessment
期中筆試
Midterm exam
期末筆試
Final exam
三次段落平均成績,段落成績包含段考及平時成績(小考、出席、作業等)。
參考書目Reference
教科書:Reginald H. Garrett and Charles M. Grisham (2017) Biochemistry, 6th ed.
參考書:
1. Thomas M. Devlin (2019) Textbook of Biochemistry with Clinical Correlations, 8th ed.
2. David L. Nelson and Michael M. Cox. (2017) Lehninger Principles of Biochemistry, 7th ed.
3. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. (2019) Biochemistry, 9th ed.
4. Victor W. Rodwell. et al. (2018) Harper’s Illustrated Biochemistry, 31th ed.
5. Denise R. Ferrier. (2017) Lippincott’s Illustrated Reviews: Biochemistry, 7th ed.
6. Mary K. Campbell and Shawn O. Farrell. (2015) Biochemistry, Taiwan ed.
教學進度Course Schedule
2020/03/06 脂質
(關鍵字: 脂肪酸,磷脂質,醣脂質(醣神經鞘脂質),複合性脂質,衍生性脂質)
(原 02/21 課程的語音檔已上傳)
lipids
(Keywords: fatty acids、phospholipids、glycolipids (glycosphingolipids)、complex lipids、derived lipids)
(The online couse has been uploaded to Moodle.)
馬明琪(Maa, Ming-Chei) 2020/03/06 脂肪酸代謝 (補課)
(關鍵字:活性脂肪酸,β-氧化,肉鹼,肉鹼梭動機制,肉鹼醯[基]轉移酶-1,過氧化體,α-氧化,ω-氧化,激素敏感(性)脂酶)
Fatty acid Catabolism
(Keywords: active fatty acid、β-oxidation、carnitine、carnitine shuttle、carnitine acyltransferase-1、peroxisomes、α-oxidation、ω-oxidation、hormone-sensitive lipase)
馬明琪(Maa, Ming-Chei) 2020/03/13 脂肪酸代謝與脂質生合成
(關鍵字:酮體,酮酸中毒,酮解作用,檸檬酸,乙醯輔酶A羧化酶,丙二醯輔酶A,脂肪酸合成酶,NADPH,去飽和酶)
Fatty acid Catabolism and Lipids Biosynthesis
(Keywords: ketone body、ketoacidosis、ketolysis、citrate、acetyl CoA carboxylase、malonyl CoA、fatty acid synthase、NADPH、desaturases)
馬明琪(Maa, Ming-Chei) 2020/03/20 膽固醇代謝
(關鍵字: 甲羥戊酸,類異戊二烯,角鯊烯,羊毛固醇,法尼基焦磷酸,HMG-CoA還原酶,固醇調節元件結合蛋白,醯基輔酶A:膽固醇醯基轉移酶,乳糜微粒,極低密度脂蛋白(VLDL或前β-脂蛋白),低密度脂蛋白(LDL或β-脂蛋白),高密度脂蛋白(HDL或α-脂蛋白),脂蛋白元,逆向膽固醇輸送,卵磷脂:膽固醇醯基轉移酶,膽酸,動脈粥樣硬化,冠心病)
Cholesterol Metabolism
(Keywords: mevalonate、isoprenoid、squalene、lanosterol、farnesyl diphosphate、HMG-CoA reductase、sterol regulatory element-binding protein、acyl-CoA:cholesterol acyltransferase、chylomicrons、very low density lipoproteins (VLDL, or pre-β-lipoproteins)、low-density lipoproteins (LDL, or β-lipoproteins)、high-density lipoproteins (HDL, or α-lipoproteins)、apolipoproteins、reverse cholesterol transport、lecithin:cholesterol acyltransferase、bile acids、atherosclerosis、coronary heart disease)
馬明琪(Maa, Ming-Chei) 2020/03/27 胺基酸代謝
(關鍵字: 泛素,蛋白酶體,丙胺酸,麩醯胺酸,轉胺作用,氧化去胺作用,氨運輸,尿素循環)
Nitrogen Acquisition and Amino Acid Metabolism
(Keywords: ubiquitin、proteasome、alanine、glutamine、transamination、oxidative deamination、ammonia transport、urea cycle)
馬明琪(Maa, Ming-Chei) 2020/03/31 第一次段考:星期二 12:10 ~ 13:00,範圍: 2/21~3/20上課內容
The First Examination: 12:10 ~ 13:00,
Lectures: 2/21~3/20.
馬明琪(Maa, Ming-Chei) 2020/04/10 胺基酸代謝
(關鍵字: 產糖性胺基酸,產酮性胺基酸,苯酮尿症,黑尿症,S-腺苷甲硫胺酸,楓糖尿病,必需胺基酸,α-酮戊二酸,草醯乙酸,3-磷甘油酸)
Nitrogen Acquisition and Amino Acid Metabolism
(Keywords: glucogenic amino acid、ketogenic amino acid、phenylketonuria alkaptonuria、S-adenosylmethionine、maple syrup urine disease、essential amino acid、α-ketoglutarate、oxaloacetate、3-phosphoglycerate)
馬明琪(Maa, Ming-Chei) 2020/04/17 血基質代謝與胺基酸轉變成特殊產物
(關鍵字: 肌酸,一氧化氮,多胺腐胺,精液素,精胺酸,血清素,褪黑激素,腎上腺素,三碘甲狀腺胺酸,甲狀腺素,組織胺,黑色素,血紅素蛋白,δ-胺基乙醯丙酸(ALA),紫質,紫質症,膽紅素,黃疸)
Metabolism of Heme and Conversion of Amino Acids to Specialized Products
(Keywords: creatine、nitric oxide、polyamines putrescine、spermine、spermidine、serotonin、melatonin、epinephrine、triiodothyronine、thyroxine、histamine、melanin、hemoproteins、δ-aminolevulinate (ALA)、porphyrins、porphyrias、bilirubin、jaundice)
馬明琪(Maa, Ming-Chei) 2020/04/24 核苷酸的合成及降解
(關鍵字: 嘌呤,嘧啶,5-磷酸核糖-5-焦磷酸,次黃嘌呤核苷酸,反饋調節,再利用路徑,核糖核苷酸還原酶,氨基甲醯磷酸合成酶II,尿酸,痛風,腺苷脫氨酶缺乏症,抗癌藥物)
Synthesis and Degradation of Nucleotides
(Keywords: purines、pyrimidines、5-phosphoribosyl 5-pyrophosphate、inosine monophosphate、feedback regulation、salvage pathway、ribonucleotide reductase、carbamoyl phosphate synthetase II、uric acid、gout、adenosine deaminase deficiency、 anticancer drugs)
張乃文(Nai-Wen Chang) 2020/05/01 核苷酸的合成及降解
(關鍵字: 嘌呤,嘧啶,5-磷酸核糖-5-焦磷酸,次黃嘌呤核苷酸,反饋調節,再利用路徑,核糖核苷酸還原酶,氨基甲醯磷酸合成酶II,尿酸,痛風,腺苷脫氨酶缺乏症,抗癌藥物)
Synthesis and Degradation of Nucleotides
(Keywords: purines、pyrimidines、5-phosphoribosyl 5-pyrophosphate、inosine monophosphate、feedback regulation、salvage pathway、ribonucleotide reductase、carbamoyl phosphate synthetase II、uric acid、gout、adenosine deaminase deficiency、 anticancer drugs)
張乃文(Nai-Wen Chang) 2020/05/05 第二次段考:星期二 12:10 ~ 13:00,範圍: 3/27~5/01授課內容
The Second Examination: 12:10 ~ 13:00,
Lectures: 3/27~5/01.
馬明琪(Maa, Ming-Chei) 2020/05/08 代謝整合與器官的專一性
(關鍵字: 合成代謝途徑,分解代謝途徑,兩用代謝路徑,肥胖,能量電荷,AMP-活化蛋白激酶(AMPK),良好進食狀態,禁食狀態,葡萄糖恆定,進食行為,產生黑皮質素的神經元,產生NPY / AgRP的神經元,熱量限制,去乙醯化酶(NAD+-依賴去乙醯化酶)
Metabolic Integration and Organ Specialization
(Keywords: anabolic pathways、catabolic pathways、amphibolic pathways、obesity、energy charge、AMP-activated protein kinase (AMPK)、well-fed state、fasting state、glucose homeostasis、eating behavior、melanocortin-producing neurons、NPY/AgRP-producing neurons、caloric restriction、sirtuins (NAD+-dependent protein deacetylases)
張乃文(Nai-Wen Chang) 2020/05/15 代謝整合與器官的專一性
(關鍵字: 合成代謝途徑,分解代謝途徑,兩用代謝路徑,肥胖,能量電荷,AMP-活化蛋白激酶(AMPK),良好進食狀態,禁食狀態,葡萄糖恆定,進食行為,產生黑皮質素的神經元,產生NPY / AgRP的神經元,熱量限制,去乙醯化酶(NAD+-依賴去乙醯化酶)
Metabolic Integration and Organ Specialization
(Keywords: anabolic pathways、catabolic pathways、amphibolic pathways、obesity、energy charge、AMP-activated protein kinase (AMPK)、well-fed state、fasting state、glucose homeostasis、eating behavior、melanocortin-producing neurons、NPY/AgRP-producing neurons、caloric restriction、sirtuins (NAD+-dependent protein deacetylases)
張乃文(Nai-Wen Chang) 2020/05/22 膜與膜的轉運
(關鍵字: 脂質雙層,選擇性滲透性,轉運蛋白,離子通道,整合蛋白,周邊蛋白,液體鑲嵌模型,脂膜筏,胞膜窖,促進擴散,主動轉輸,水通道蛋白,胞吐作用,胞飲作用,裂隙接合,細胞間相互作用,跨膜信號傳導)
Metabolic Integration and Organ Specialization
(Keywords: anabolic pathways、catabolic pathways、amphibolic pathways、obesity、energy charge、AMP-activated protein kinase (AMPK)、well-fed state、fasting state、glucose homeostasis、eating behavior、melanocortin-producing neurons、NPY/AgRP-producing neurons、caloric restriction、sirtuins (NAD+-dependent protein deacetylases)
Membranes and Membrane transport
(Keywords: lipid bilayer、selective permeabilities、transporters、ion channels、integral proteins、peripheral proteins、fluid mosaic model、lipid rafts、caveolae、facilitated diffusion、active transport、aquaporins、exocytosis、endocytosis、gap junctions、cell–cell interactions、transmembrane signaling)
張乃文(Nai-Wen Chang) 2020/05/29 膜與膜的轉運
(關鍵字: 脂質雙層,選擇性滲透性,轉運蛋白,離子通道,整合蛋白,周邊蛋白,液體鑲嵌模型,脂膜筏,胞膜窖,促進擴散,主動轉輸,水通道蛋白,胞吐作用,胞飲作用,裂隙接合,細胞間相互作用,跨膜信號傳導)
Membranes and Membrane transport
(Keywords: lipid bilayer、selective permeabilities、transporters、ion channels、integral proteins、peripheral proteins、fluid mosaic model、lipid rafts、caveolae、facilitated diffusion、active transport、aquaporins、exocytosis、endocytosis、gap junctions、cell–cell interactions、transmembrane signaling)
張乃文(Nai-Wen Chang) 2020/06/05 細胞外信息的接收與傳遞
(關鍵字: 親脂性激素,胜肽和兒茶酚胺激素,G蛋白偶聯接受器(GPCR),第二信使,接受器酪氨酸激酶(RTK),接受器鳥苷酸環化酶(RGC),MAPK途徑)
The Reception and Transmission of extracellular Information
(Keywords: lipophilic hormones、peptide & catecholamine hormones、G protein–coupled receptors (GPCR)、second messengers、receptor tyrosine kinase (RTK)、receptor guanylyl cyclase (RGC)、MAPK pathway)
張乃文(Nai-Wen Chang) 2020/06/12 細胞外信息的接收與傳遞
(關鍵字: 親脂性激素,胜肽和兒茶酚胺激素,G蛋白偶聯接受器(GPCR),第二信使,接受器酪氨酸激酶(RTK),接受器鳥苷酸環化酶(RGC),MAPK途徑)
The Reception and Transmission of extracellular Information
(Keywords: lipophilic hormones、peptide & catecholamine hormones、G protein–coupled receptors (GPCR)、second messengers、receptor tyrosine kinase (RTK)、receptor guanylyl cyclase (RGC)、MAPK pathway)
張乃文(Nai-Wen Chang) 2020/06/16 第三次段考:星期二12:10 ~ 13:00,範圍: 5/08~6/12上課
Final Examination: 12:10 ~ 13:00, Lectures: 5/08~6/12
張乃文(Nai-Wen Chang) 2020/06/23 彈性教學 2020/06/30 彈性教學