1. 介紹構成生物體的基本組成，例如：蛋白質、醣類、核酸、脂質等，並探討其特性及對生命現象的貢獻。
2. 認識生物體內物質產生與分解的過程，並了解基礎代謝化學反應、結構-功能的相關性、酵素調控、能量的產生與轉換。
3. 整合代謝路徑的調控，了解調控異常所導致的疾病。
1. To introduce the composition and characters of biological molecules (proteins, carbohydrates, nucleotides, lipids) and their contributions to live.
2. To understand the synthesis and degradation of biological molecules, the metabolic pathways, structure-function correlations, enzyme kinetics, and energy metabolism.
3. To integrate biochemical processes and understand related diseases.
教科書：Reginald H. Garrett and Charles M. Grisham (2017) Biochemistry, 6th ed.
參考書： 1. Thomas M. Devlin (2019) Textbook of Biochemistry with Clinical Correlations, 8th ed.
2. David L. Nelson and Michael M. Cox. (2017) Lehninger Principles of Biochemistry, 7th ed.
3. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. (2019) Biochemistry, 9th ed.
4. Victor W. Rodwell. et al. (2018) Harper’s Illustrated Biochemistry, 31th ed.
5. Denise R. Ferrier. (2017) Lippincott’s Illustrated Reviews: Biochemistry, 7th ed.
6. Mary K. Campbell and Shawn O. Farrell. (2015) Biochemistry, Taiwan ed.
教學進度Course Schedule
2022/09/16 生化學簡介 [ch.1, 2] [生物分子、細胞特性、Henderson-Hasselbalch equation、酸鹼值、緩衝系統]
Introduction to Biochemistry [Biomolecules, Properties of cells, Henderson-Hasselbalch equation, pH value, Buffer system]
葉威蘭(Yeh, Wei-Lan) 2022/09/23 胺基酸與胜肽 [ch.4] [胺基酸、胜肽鍵、等電點]
Amino Acids and Peptides [Amino acids, Peptide bond, Isoelectric point]
葉威蘭(Yeh, Wei-Lan) 2022/09/30 蛋白質的結構 [ch.5] [蛋白質的分離與純化、胺基酸分析、胺基酸定序、多胜肽的化學合成、蛋白質體]
Proteins: Their Primary Structure and Biological Functions [Isolation and purification of proteins, Amino acid analysis, Amino acid sequencing, Chemical synthesis of polypeptides, Proteome]
葉威蘭(Yeh, Wei-Lan) 2022/10/07 蛋白質的三D立體的結構 [ch.6] [蛋白質一、二、三、四級結構的特性、胜肽與蛋白質的特性、蛋白質變性、α-角蛋白、膠原蛋白]
Proteins: Secondary, Tertiary, and Quaternary Structure [Characteristics of protein 1, 2, 3, and 4 structures, Properties of peptides and proteins, Protein denaturation, α-Keratin, Collagen]
葉威蘭(Yeh, Wei-Lan) 2022/10/14 蛋白質: 肌紅素與血紅素 [ch.15] [肌紅素、血紅素、協同性、S型曲線、Bohr效應]
Proteins: Myoglobin and Hemoglobin [Myoglobin, Hemoglobin, Cooperativity, Sigmoid curve, Bohr effect]
葉威蘭(Yeh, Wei-Lan) 2022/10/21 酵素:基本概念和動力學 [ch.13] [酵素動力學、KM、Kcat、Kcat/KM、酵素活性的抑制作用]
Enzymes: Basic Concepts and Kinetics [Enzyme kinetics, KM, Kcat, Kcat/KM, Inhibition of enzyme activity]
葉威蘭(Yeh, Wei-Lan) 2022/10/28 酵素的作用機制 [ch.14] [過渡狀態、活化位、酵素催化的機轉]
Mechanisms of Enzyme Action [Transition-state, Active site, Mechanisms of catalysis]
葉威蘭(Yeh, Wei-Lan) 2022/11/04 酵素的調控機制 [ch.15] [共價修飾、異位調控、同功酶、酶原]
Enzyme Regulation [Covalent modification, Allosteric regulation, Isozyme, Proenzyme]
葉威蘭(Yeh, Wei-Lan) 2022/11/11 期中考
Midterm Exam
葉威蘭(Yeh, Wei-Lan) 2022/11/18 維生素: 需要量與功能[水溶性維生素、脂溶性維生素、輔酶]
Vitamins: Requirements and Function [Water-soluble Vitamins, Fat-soluble Vitamins, Coenzyme)]
王志豪(Wang, Chih-Hao) 2022/11/25 醣類 [ch.7] [醣類、糖苷鍵、醣胺聚醣、蛋白聚醣、醣蛋白]
Carbohydrates [Carbohydrates, Glycosidic bond, Glycosaminoglycans, Proteoglycan, Glycoprotein]
王志豪(Wang, Chih-Hao) 2022/12/02 糖解作用 [ch.18] [糖解作用、丙酮酸、乳酸]
Glycolysis [Glycolysis, Pyruvate, Lactate]
王志豪(Wang, Chih-Hao) 2022/12/09 檸檬酸循環 [ch.19] [三羧酸循環、丙酮酸去氫酶複合體、草醯乙酸、三羧酸循環的調節]
The Citric Acid Cycle [TCA cycle, Pyruvate dehydrogenase complex, Oxaloacetate, Regulation of TCA cycle]
王志豪(Wang, Chih-Hao) 2022/12/16 氧化磷酸化作用 [ch.20] [電子的傳遞、氧化磷酸化作用、ATP合成酶、化學滲透假說]
Oxidative Phosphorylation [Electron transport, Oxidative phosphorylation, ATP synthase, Chemiosmotic hypothesis]
王志豪(Wang, Chih-Hao) 2022/12/23 糖新生作用 [ch.22] [糖新生作用、升糖素、胰島素、腎上腺素]
Gluconeogenesis [Gluconeogenesis, Glucagon, Insulin, Epinephrine]
王志豪(Wang, Chih-Hao) 2022/12/30 肝醣的代謝 [ch.22] [肝醣、葡萄糖6-磷酸酶、肝醣貯積症、升糖素、胰島素、腎上腺素]
Glycogen Metabolism [Glycogen, Glucose 6-phosphatase, Glycogen-storage disease, Glucagon, Insulin, Epinephrine]
王志豪(Wang, Chih-Hao) 2023/01/06 五碳糖磷酸路徑 [ch.22] [五碳糖磷酸代謝途徑、葡萄糖6-磷酸去氫酶、NADPH、核糖5-磷酸]
The Pentose Phosphate Pathway [Pentose phosphate pathway, Glucose 6-phosphate dehydrogenase, NADPH, Ribose 5-phosphate]
王志豪(Wang, Chih-Hao) 2023/01/13 期末考
Final Exam
王志豪(Wang, Chih-Hao)