要求學生充分熟悉： 1. 生物分子之種類、物理化學性質及其生物功能 2. 了解生化原理，包括:結構-功能相關性，化學活性，酵素動力學與平衡、熱力學，生物膜結構及功能，能量代謝路徑、代謝整合及調節 3. 生物分子之新陳代謝及其調控異常所導致的疾病。
The intention of the course for students is to 1. know the composition, structure, and function of the major classes of biological molecules. 2. understand the biochemical principles, including: structure-function correlation, chemical reactivity, enzyme kinetics and equilibrium, thermodynamics, membrane structure and function, metabolic pathways of energy, and integration and regulation of metabolism. 3. understand how improper regulation of these biochemical processes can lead to human diseases.
期中筆試
Midterm exam
期末筆試
Final exam
出席狀況
Class attendance
三次段落平均成績，段落成績包含段考及平時成績(小考、出席、作業等)。
參考書目Reference
教科書：Reginald H. Garrett and Charles M. Grisham (2017) Biochemistry, 6th ed. 參考書： 1. Thomas M. Devlin (2019) Textbook of Biochemistry with Clinical Correlations, 8th ed. 2. Christopher K. Mathews, et al. (2013) Biochemistry, 4th ed. 3. David L. Nelson and Michael M. Cox. (2017) Lehninger Principles of Biochemistry, 7th ed. 4. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. (2015) Biochemistry, 8th ed. 5. Victor W. Rodwell. et al. (2018) Harper’s Illustrated Biochemistry, 31th ed. 6. Denise R. Ferrier. (2017) Lippincott’s Illustrated Reviews: Biochemistry, 7th ed. 7. Mary K. Campbell and Shawn O. Farrell. (2015) Biochemistry, Taiwan ed.
教學進度Course Schedule
2023/09/15 生化學簡介 (關鍵字:生物分子、細胞特性、Henderson-Hasselbalch equation、酸鹼值、緩衝系統)
Introduction to Biochemistry (Keywords: Biomolecules, Properties of cells, Henderson-Hasselbalch equation, pH value, Buffer system)
黄琮竣(Huang, Tsurng-Juhn) 2023/09/22 胺基酸與胜肽 (關鍵字:胺基酸、胜肽鍵、等電點)
Amino Acids and Peptides (Keywords: Amino acids, Peptide bond, Isoelectric point)
黄琮竣(Huang, Tsurng-Juhn) 2023/09/29 中秋節放假
Holiday
黄琮竣(Huang, Tsurng-Juhn) 2023/10/06 蛋白質:一級、二級、三級及四級構造 (關鍵字:蛋白質一、二、三、四級結構的特性、胜肽與蛋白質的特性、蛋白質變性、α-角蛋白、膠原蛋白)
蛋白質: 肌紅素與血紅素 (關鍵字:肌紅素、血紅素、協同性、S型曲線、Bohr效應)
Proteins: Primary, Secondary, Tertiary, and Quaternary Structures (Keywords: Characteristics of protein 1, 2, 3, and 4 structures, Properties of peptides and proteins, Protein denaturation, α-Keratin, Collagen)
Proteins: Myoglobin and Hemoglobin (Keywords: Myoglobin, Hemoglobin, Cooperativity, Sigmoid curve, Bohr effect)
黄琮竣(Huang, Tsurng-Juhn) 2023/10/13 分析蛋白質 (關鍵字:蛋白質的分離與純化、胺基酸分析、胺基酸定序、多胜肽的化學合成、蛋白質體)
Working with Proteins (Keywords: Isolation and purification of proteins, Amino acid analysis, Amino acid sequencing, Chemical synthesis of polypeptides, Proteome)
黄琮竣(Huang, Tsurng-Juhn) 2023/10/20 酵素:基本概念和動力學 (關鍵字:酵素動力學、KM、Kcat、Kcat/KM、酵素活性的抑制作用)
Enzymes: Basic Concepts and Kinetics (Keywords: Enzyme kinetics, KM, Kcat, Kcat/KM, Inhibition of enzyme activity)
鍾瑋敏(Chung, Wei-Min) 2023/10/27 酵素的作用機制 (關鍵字:過渡狀態、活化位、酵素催化的機轉)
Mechanisms of Enzyme Action (Keywords: Transition-state, Active site, Mechanisms of catalysis)
黄琮竣(Huang, Tsurng-Juhn) 2023/11/03 酵素的調控機制 (關鍵字:共價修飾、異位調控、同功酶、酶原)
Enzyme Regulation (Keywords: Covalent modification, Allosteric regulation, Isozyme, Proenzyme)
黄琮竣(Huang, Tsurng-Juhn) 2023/11/10 期中考：10:10 ~ 11:00，範圍: 9/15~11/03授課內容
The Mid-term: 10:10 ~ 12:00, Lectures: 2023/09/15~2023/11/03.
黄琮竣(Huang, Tsurng-Juhn) 2023/11/17 維生素: 需要量與功能 (關鍵字:水溶性維生素、脂溶性維生素、輔酶)(2021台灣國際創新生物醫學峰會: 專題演講)
Vitamins: Requirements and Function (Keywords: Water-soluble Vitamins, Fat-soluble Vitamins, Coenzyme)(2021 Taiwan International Innovative Biomedical Summit: Keynote speech)
黄琮竣(Huang, Tsurng-Juhn) 2023/11/24 醣類 (關鍵字:醣類、糖苷鍵、醣胺聚醣、蛋白聚醣、醣蛋白)
Carbohydrates (Keywords: Carbohydrates, Glycosidic bond, Glycosaminoglycans, Proteoglycan, Glycoprotein)
黄琮竣(Huang, Tsurng-Juhn) 2023/12/01 糖解作用 (關鍵字:糖解作用、丙酮酸、乳酸)
Glycolysis (Keywords: Glycolysis, Pyruvate, Lactate)
黄琮竣(Huang, Tsurng-Juhn) 2023/12/08 檸檬酸循環 (關鍵字:三羧酸循環、丙酮酸去氫酶複合體、草醯乙酸、三羧酸循環的調節)
The Citric Acid Cycle (Keywords: TCA cycle, Pyruvate dehydrogenase complex, Oxaloacetate, Regulation of TCA cycle)
黄琮竣(Huang, Tsurng-Juhn) 2023/12/15 氧化磷酸化作用 (關鍵字:電子的傳遞、氧化磷酸化作用、ATP合成酶、化學滲透假說)
Oxidative Phosphorylation (Keywords: Electron transport, Oxidative phosphorylation, ATP synthase, Chemiosmotic hypothesis)
黄琮竣(Huang, Tsurng-Juhn) 2023/12/22 糖質新生作用 (關鍵字:糖新生作用、升糖素、胰島素、腎上腺素)
肝醣的代謝 (關鍵字:肝醣、葡萄糖6-磷酸酶、肝醣貯積症、升糖素、胰島素、腎上腺素)
Gluconeogenesis (Keywords: Gluconeogenesis, Glucagon, Insulin, Epinephrine)
Glycogen Metabolism (Keywords: Glycogen, Glucose 6-phosphatase, Glycogen-storage disease, Glucagon, Insulin, Epinephrine)
黄琮竣(Huang, Tsurng-Juhn) 2023/12/29 元旦補假
Holiday
黄琮竣(Huang, Tsurng-Juhn) 2024/01/05 五碳糖磷酸路徑 (關鍵字:五碳糖磷酸代謝途徑、葡萄糖6-磷酸去氫酶、NADPH、核糖5-磷酸)
The Pentose Phosphate Pathway (Keywords: Pentose phosphate pathway, Glucose 6-phosphate dehydrogenase, NADPH, Ribose 5-phosphate)
黄琮竣(Huang, Tsurng-Juhn) 2024/01/12 期末考：星期二10:10 ~ 11:00，範圍: 11/17~01/05授課內容
The Third Examination: 10:10 ~ 11:00, Lectures 2023/1/17~2024/01/05.
黄琮竣(Huang, Tsurng-Juhn)