要求學生充分熟悉：
1. 生物分子之種類、物理化學性質及其生物功能
2. 了解生化原理，包括:結構-功能相關性，化學活性，酵素動力學與平衡、熱力學，生物膜結構及功能，能量代謝路徑、代謝整合及調節
3. 生物分子之新陳代謝及其調控異常所導致的疾病。
The intention of the course for students is to 1. know the composition, structure, and function of the major classes of biological molecules 2. understand the biochemical principles, including: structure-function correlation, chemical reactivity, enzyme kinetics and equilibrium, thermodynamics, membrane structure and function, metabolic pathways of energy, and integration and regulation of metabolism 3. understand how improper regulation of these biochemical processes can lead to human diseases.
先修科目Prerequisites
生物學、普通化學
Biology, General Chemistry
教學方式Teaching Methods
講課
Lecturing
腦力激盪
Brain storming
習題練習
Exercise
影片欣賞與討論
Movie review and discussions
評量方式Assessment
期中筆試
Midterm exam
隨堂筆試測驗
In-class exam
期末筆試
Final exam
出席狀況
Class attendance
課堂參與與表現
Class involvement
三次段落平均成績，段落成績包含段考及平時成績(小考、出席、作業等)。
參考書目Reference
教科書：Reginald H. Garrett and Charles M. Grisham (2017) Biochemistry, 6th ed.
參考書：
1. Thomas M. Devlin (2011) Textbook of Biochemistry with Clinical Correlations, 7h ed.
2. Christopher K. Mathews, et al. (2013) Biochemistry, 4th ed.
3. David L. Nelson and Michael M. Cox. (2017) Lehninger Principles of Biochemistry, 7th ed.
4. Jeremy M. Berg, John L. Tymoczko, Lubert Stryer. (2019) Biochemistry, 9th ed.
5. Victor W. Rodwell. et al. (2018) Harper’s Illustrated Biochemistry, 31th ed.
6. Denise R. Ferrier. (2017) Lippincott’s Illustrated Reviews: Biochemistry, 7th ed.
7. Mary K. Campbell and Shawn O. Farrell. (2015) Biochemistry, Taiwan ed.
教學進度Course Schedule
2020/03/05 脂質
(關鍵字: 脂肪酸；反式脂肪酸；三酸甘油酯；甘油磷酯質；神經鞘脂質；醣脂質；膽固醇；類固醇)
**(本次課程採線上教學，請到 moodle 系統進行自主學習。 影音檔上傳日期：2/12)
Lipids
(Keywords: Fatty acids; Trans fatty acids; Triacylglycerol; Glycerophospholipids; Sphingolipids; Glycolipids; Cholesterol; Steroid)
**Online self-learning
張乃文(Nai-Wen Chang) 2020/03/05 脂肪酸代謝
(關鍵字: 激素引發脂肪組織中脂肪酸的釋放；膳食脂質的消化；吸收和分泌；beta-氧化)
**(本次課程採線上教學，請到 moodle 系統進行自主學習。 影音檔上傳日期：2/12)
Fatty Acid Catabolism
(Keywords: Hormones trigger the release of fatty acids from adipose tissue; Digestion, absorption, and secretion of dietary lipids; Beta-oxidation)
**Online self-learning
張乃文(Nai-Wen Chang) 2020/03/05 脂肪酸代謝與脂質生合成
(關鍵字: 酮體的合成；酮體利用；酮病；酮酸中毒；脂肪酸生合成；延長作用；去飽和作用)
Fatty Acid Catabolism and Lipids Biosynthesis
(Keywords: Synthesis of ketone bodies; Utilization of ketone bodies; Ketosis; Ketoacidosis; Fatty acid biosynthesis; Elongation; Desaturation)
張乃文(Nai-Wen Chang) 2020/03/12 脂質生合成
(關鍵字: 甘油磷酯質；三酸甘油酯；神經醯胺；類花生酸)
Lipids Biosynthesis
(Keywords: Glycerolipids; Triacylglycerol; Ceramide; Eicosanoids)
張乃文(Nai-Wen Chang) 2020/03/19 膽固醇代謝
(關鍵字: 膽固醇；HMG-CoA還原酶的調節；脂蛋白；脂蛋白元；反向膽固醇運輸；家族性高膽固醇血症)
Cholesterol Metabolism
(Keywords: Cholesterol; Regulation of HMG-CoA reductase; Lipoproteins; Apolipoproteins; Reverse cholesterol transport; Familial hypercholesterolemia)
張乃文(Nai-Wen Chang) 2020/03/26 胺基酸代謝
(關鍵字: 硝酸鹽同化作用；固氮作用；轉胺作用；葡萄糖-丙氨酸循環；尿素循環)
Nitrogen Acquisition and Amino Acid Metabolism
(Keywords: Nitrate assimilation; Nitrogen fixation; Transamination; Glucose-alanine cycle; Urea cycle)
張乃文(Nai-Wen Chang) 2020/03/31 第一次段考：星期二 12:10 ~ 13:00，範圍:2/20~3/19上課內容
The First Examination:
12:10 ~ 13:00, Lectures:2020/02/20~2020/03/19.
張乃文(Nai-Wen Chang) 2020/04/09 胺基酸代謝
(關鍵字: 產糖性胺基酸；產酮性胺基酸；苯酮尿症；黑尿症；楓糖漿尿病)
Nitrogen Acquisition and Amino Acid Metabolism
(Keywords: Glucogenic amino acids; Ketogenic amino acids; Phenylketonuria; Alkaptonuria; Maple syrup urine disease)
張乃文(Nai-Wen Chang) 2020/04/16 血基質代謝與胺基酸轉變成特殊產物
(關鍵字: 卟啉的合成；血基質的形成；紫質症；膽紅素；黃疸；兒茶酚胺；血清素)
Metabolism of Heme and Conversion of Amino Acids to Specialized Products
(Keywords: Porphyrin synthesis; Formation of heme; Porphyria; Bilirubin; Jaundice; Catecholamines; Serotonin)
馬明琪(Maa, Ming-Chei) 2020/04/23 核苷酸的合成及降解
(關鍵字：新生途徑；嘌呤生合成的調控；救援途徑；嘌呤的代謝)
Synthesis and Degradation of Nucleotides
(Keywords: de novo pathway; Regulation of purine biosynthesis; Salvage pathway; Purine catabolism)
馬明琪(Maa, Ming-Chei) 2020/04/30 核苷酸的合成及降解
(關鍵字：新生途徑；嘌呤生合成的調控；救援途徑；嘌呤的代謝)
Synthesis and Degradation of Nucleotides
(Keywords: de novo pathway; Regulation of purine biosynthesis; Salvage pathway; Purine catabolism)
馬明琪(Maa, Ming-Chei) 2020/05/05 第二次段考：星期二 12:10 ~ 13:00，範圍: 3/26~4/30上課內容
The Second Examination: 12:10 ~ 13:00，Lectures:
2020/03/26~2020/04/30.
馬明琪(Maa, Ming-Chei) 2020/05/07 代謝整合與器官的專一性
(關鍵字：新陳代謝；生化物質的合成；生化物質的分解；能量估值；AMPK調控全身能量的動態平衡)
Metabolic Integration and Organ Specialization
(Keywords: Metabolism; Anabolism, Catabolism; Energy charge; AMPK controls whole body energy homeostasis)
馬明琪(Maa, Ming-Chei) 2020/05/14 代謝整合與器官的專一性
(關鍵字：代謝整合；飲食行為；長壽)
Metabolic Integration and Organ Specialization
(Keywords: Metabolism integration; Eating behavior; Longevity)
馬明琪(Maa, Ming-Chei) 2020/05/21 膜與膜的轉運
(關鍵字：細胞膜的理化性質；膜蛋白結構與化學性質；細胞膜的組織架構；影響細胞膜的動態過程)
Membranes and Membrane transport
(Keywords: Physical and chemical properties of cell membrane; Structure and chemistry of membrane proteins; Organization of membrane; Dynamic processes that modulate membrane function)
張乃文(Nai-Wen Chang) 2020/05/28 膜與膜的轉運
(關鍵字：被動擴散；加速擴散；主動運輸；離子梯度主導的二次主動運輸膜)
Membranes and Membrane transport
(Keywords: Passive diffusion; Facilitated diffusion; Active transport; Secondary active transport driven by ion gradients)
張乃文(Nai-Wen Chang) 2020/06/04 細胞外信息的接收與傳遞
(關鍵字：賀爾蒙；訊息傳遞；受體)
The Reception and Transmission of extracellular Information
(Keywords: Hormones; Signal transduction; Receptors)
馬明琪(Maa, Ming-Chei) 2020/06/11 細胞外信息的接收與傳遞
(關鍵字：第二訊息傳遞者；致癌基因；抑癌基因；訊息整合)
The Reception and Transmission of extracellular Information
(Keywords: Second messengers; Oncogenes; Tumor suppressors; Signal integration)
馬明琪(Maa, Ming-Chei) 2020/06/16 第三次段考：星期二12:10 ~ 13:00，範圍: 5/7~6/11上課內容
Final Examination: 12:10 ~ 13:00, Lectures: 2020/05/07~2020/06/11
馬明琪(Maa, Ming-Chei) 2020/06/23 彈性教學 2020/06/30 彈性教學