本課程旨在探討藥物透過各種途徑進入體內的動向，包含四大主題:吸收、分佈、代謝、排泄，利用數學運算來定量的描述與預測，是新藥開發前期不可或缺的一環。
This course focuses on the kinetics of a drug in the body. It includes four main topics, absorption, distribution, metabolism, and elimination. Through mathematic expression, this describes one of the essential part of new drug development.
先修科目Prerequisites
教學方式Teaching Methods
講課
Lecturing
學生實作
Student hands-on practice
小組討論、腦力激盪(如案例討論、電影欣賞等)
Group discussion, Brain storming, e.g., Case study, Event discussion, Movie review
學生上台報告、角色演練
Oral presentation, Role playing
評量方式Assessment
實作測驗
Practical exam
期中報告
Midterm report
期末報告
Final report
個人上台報告
Oral Report
出席狀況
Class attendance
課堂參與與表現
Class involvement
參考書目Reference
Leon Shargel, Andrew Yu. Biopharmaceutics & Pharmacokinetics
教學進度Course Schedule
2022/02/21 藥物動力學與生物藥劑學緒論
Introduction to Biopharmaceutics and Pharmacokinetics
葉威蘭(Yeh, Wei-Lan) 2022/02/28 基礎數學的複習
Review of Mathematical Fundamentals
盧大宇(Dah-Yuu Lu) 2022/03/07 一室開放模式
One-Compartment Open Model
盧大宇(Dah-Yuu Lu) 2022/03/14 多室模式
Multi-Compartment Models
盧大宇(Dah-Yuu Lu) 2022/03/21 藥物吸收
Drug Absorption
盧大宇(Dah-Yuu Lu) 2022/03/28 藥物分佈
Drug Distribution
葉威蘭(Yeh, Wei-Lan) 2022/04/04 藥物代謝
Drug Metabolism
葉威蘭(Yeh, Wei-Lan) 2022/04/11 期中考週
Week of Middle Exam
葉威蘭(Yeh, Wei-Lan) 2022/04/18 藥物排泄
Drug Elimination
葉威蘭(Yeh, Wei-Lan) 2022/04/25 多劑量給藥
Multiple Dosage Regimens
葉威蘭(Yeh, Wei-Lan) 2022/05/02 非線性藥物動力學
Nonlinear Pharmacokinetics
葉威蘭(Yeh, Wei-Lan) 2022/05/09 產品設計之藥物動力學考量
Pharmacokinetic Consideration in Drug Design
葉威蘭(Yeh, Wei-Lan) 2022/05/16 疾病作用下之劑量調整
Dosage Adjustment under the Effects of Diseases
葉威蘭(Yeh, Wei-Lan) 2022/05/23 靶向遞藥系統
Targeted Drug Delivery systems
葉威蘭(Yeh, Wei-Lan) 2022/05/30 藥物動力學與藥效學之間的關係
Relationship between Pharmacokinetics and Pharmacodynamics
葉威蘭(Yeh, Wei-Lan) 2022/06/06 藥物動力學之臨床應用
Pharmacokinetics in Clinical Application
葉威蘭(Yeh, Wei-Lan) 2022/06/13 期末考週
Week of Final Exam
葉威蘭(Yeh, Wei-Lan) 2022/06/20 實例探討
Case Discussion
葉威蘭(Yeh, Wei-Lan)