經由本課程的選修，期望學生得以瞭解各種癌症標靶治療藥物的作用原理及形成抗藥性的主要機制。
Targeted therapies using specific inhibitors against cell surface markers and signal transduction molecules have been viewed as promising strategies for cancer therapy. However, the development of drug resistance remains the major issue limiting their therapeutic efficacy. This lecture will (1) introduce major cellular signaling pathways involved in cancer development to identify potential targets for therapeutic interventions, (2) describe how targeted therapies may work in the treatment of various tumors, and (3) assess the current knowledge of the molecular mechanisms conferring to intrinsic/acquired resistance of targeted therapies.
先修科目Prerequisites
教學方式Teaching Methods
講課
Lecturing
評量方式Assessment
期末報告
Final report
期中考試或報告成績40%
期末考試或報告成績40%
平時上課討論及發問情形20%
參考書目Reference
1.Targeted Cancer Therapy/edited by Razelle Kurzrock, Maurie Markman/Humana Press, Totowa, NJ/2008
2.Targeted Therapies in Cancer Myth or Reality? /Colotta, Francesco and Mantovani, Alberto./SpringerLink/ 2008
3.Targeted Therapies in Oncology-Guiseppe Giacone and Jean-Charles Soria
4.Biomedical Journals