Introduction to reactive oxygen species (ROS), reactive nitrogen species (RNS), and free radicals; Chemistry and reactivity of ROS/RNS/free radicals; Lipid peroxidation; Oxidative DNA damage; Protein damage by ROS/RNS; Antioxidant enzymes; Antioxidants (drugs, nutrition, and herbal medicine); Redox regulation of gene expression; ROS/RNS in atherosclerosis and ischemia-reperfusion; ROS/RNS in inflammatory diseases and respiratory diseases; Oxidative stress and disorders of the nervous system; Oxidative stress in diabetes mellitus and eye diseases; Oxidative stress in aging and cancer.
教學目標Course Objectives
教授自由基之種類，生成原理與測定原理，了解自由基化學在生理與病理上所扮演的角色，探討中西藥物抗氧化的應用。
Understanding the types of free radicals, free radical chemistry in biological and pathological roles, explore the application of antioxidative Chinese medicines.
Halliwell B and Gutteridge JMC. Free radicals in biology and medicine. Oxford science Publications; 1999.
Sen CK, Sies H, and Baeuerle PA. Antioxidant and redox regulation of genes. Academic Press; 2000.