這門課主要在介紹結構生物資訊以及電腦輔助藥物設計的基礎知識以及相關研究課題。我們將會介紹很多相關的網頁工具、資料庫、或是已開發好的軟體，並且實際操作使用，同學必須利用這些工具來回答問題，最後並以小組方式分組實際進行專題研究。
The purpose of this course will focus on the issues of the structural bioinformatics and computer aided drug design. Various tools, databases and software that
are well developed and published on the websites will be introduced. The students are required using the public software or databases to answer the questions that the lecturer assigns.
先修科目Prerequisites
教學方式Teaching Methods
講課
Lecturing
學生課後書面報告
After class written report
學生上台報告
Oral presentation
學生實作
Student hands-on practice
習題練習
Exercise
評量方式Assessment
實作測驗
Practical exam
小組作業
Group homework
期中報告
Midterm report
期末報告
Final report
專題報告
Project report
小組上台報告
Group oral report
期中成績(30%) 期末成績(40%) 平時成績(30%)
參考書目Reference
Structural Bioinformatics, 2003, edited by Philip E. Bourne and Helge Weissig
Computational Structural Biology: Methods and Applications, 2008, edited by Torsten Schwede and Manuel Peitsch
教學進度Course Schedule
2016/09/15 中秋節
Holiday
陸志豪(Chih-Hao Lu) 2016/09/22 電腦輔助藥物設計簡介
Introduction of computer aided drug design
陸志豪(Chih-Hao Lu) 2016/09/29 蛋白質結構資料庫與工具
Databases and tools for structural biology
陸志豪(Chih-Hao Lu) 2016/10/06 蛋白質結構資料庫與工具
Databases and tools for structural biology
陸志豪(Chih-Hao Lu) 2016/10/13 蛋白質結構視覺化工具PyMOL
PyMOL
陸志豪(Chih-Hao Lu) 2016/10/20 蛋白質結構視覺化工具PyMOL
PyMOL
陸志豪(Chih-Hao Lu) 2016/10/27 實驗動物模型應用
Application for animal models
張瓈云(Sunny LY Chang) 2016/11/03 抗菌藥物的標靶設計與搜尋
Design and screening of anti-bacterial drug
林靖婷(Ching-Ting Lin) 2016/11/10 期中考
Mid-term exam
張顥騰(Hao-Teng Chang) 2016/11/17 蛋白質體與偵測生物標的
Protemics and biomarker discovery
張顥騰(Hao-Teng Chang) 2016/11/24 電腦輔助藥物設計原理
Computer aided drug design and Gemdock
陸志豪(Chih-Hao Lu) 2016/12/01 電腦輔助藥物設計原理
Computer aided drug design and Gemdock
陸志豪(Chih-Hao Lu) 2016/12/08 電腦輔助藥物設計實作
Computer aided drug design and Gemdock
陸志豪(Chih-Hao Lu) 2016/12/15 電腦輔助藥物設計實作
Computer aided drug design and Gemdock
陸志豪(Chih-Hao Lu) 2016/12/22 蛋白質結構預測與同源模擬
Structure prediction and homology modeling
陸志豪(Chih-Hao Lu) 2016/12/29 分子動態模擬
Molecular simulation
陸志豪(Chih-Hao Lu) 2017/01/05 期末專題報告
Final project report
陸志豪(Chih-Hao Lu) 2017/01/12 期末專題報告
Final project report
陸志豪(Chih-Hao Lu)