「進階計算生物學」這門課主要在教導學生結合網路上的工具及親自撰寫電腦程式來進行一些計算生物學上的研究,所以在課程的開始主要在加強程式語言撰寫的技巧以及如何與現有的工具做連結,之後我們將分別針對以下課題進行探討,其中包括,序列比對、多重序列比對、分群分類法、蛋白質能量計算、交互作用區域偵測、機器學習以及基因演算法等。學生必須透過實際撰寫程式的研究方法製作期末專題,以對計算生物學進行深入的研究。
The course is a practical, hands-on approach to the field of computational molecular biology. Various existing methods will be critically described and the algorithm of each will be discussed. For example, dynamic programming, sequence alignment, multiple sequence alignment, clustering, calculation of potential energy, binding site detection, machine learning method and genetic algorithm. Students will have practical assignments utilizing the tools described and have a final project of computational molecular biology.
1. Introduction to Computational Molecular Biology : 1997, edited by Joao Carlos Setubal, Joao Meidanis
2. Computational Molecular Biology (An Algorithmic Approach) : 2000, edited by Pavel A. Pevzner
教學進度Course Schedule
2018/09/10 基本程式設計
Basic programming
陸志豪(Chih-Hao Lu) 2018/09/17 陣列與排序
Array and sorting
陸志豪(Chih-Hao Lu) 2018/09/24 中秋節放假
Holiday
陸志豪(Chih-Hao Lu) 2018/10/01 檔案處理
File processing
陸志豪(Chih-Hao Lu) 2018/10/08 邏輯與演算法
Logic and algorithm
陸志豪(Chih-Hao Lu) 2018/10/15 序列比對
Sequence alignment
陸志豪(Chih-Hao Lu) 2018/10/22 分群分類方法
Clustering methods
陸志豪(Chih-Hao Lu) 2018/10/29 序列比對與多重序列比對
Sequence alignment and Multiple sequence alignment
陸志豪(Chih-Hao Lu) 2018/11/05 蛋白質結構檔案的讀取
PDB parser
陸志豪(Chih-Hao Lu) 2018/11/12 原子間距離、角度、雙面角的計算
Calculation of distance, angle and torsion angle
陸志豪(Chih-Hao Lu) 2018/11/19 蛋白質中能量的計算
Calculation of potential energy
陸志豪(Chih-Hao Lu) 2018/11/26 蛋白質與小分子的交互作用區域偵測
Protein binding site detection
陸志豪(Chih-Hao Lu) 2018/12/03 蛋白質與小分子的交互作用區域偵測
Protein binding site detection
陸志豪(Chih-Hao Lu) 2018/12/10 機器學習在生物資訊上的應用
Application of Machine learning methods in bioinformatics
陸志豪(Chih-Hao Lu) 2018/12/17 機器學習在生物資訊上的應用
Application of Machine learning methods in bioinformatics
陸志豪(Chih-Hao Lu) 2018/12/24 基因演算法
Genetic algorithm
陸志豪(Chih-Hao Lu) 2018/12/31 元旦彈性放假
Holiday
陸志豪(Chih-Hao Lu) 2019/01/07 期末專題報告
Final project report
陸志豪(Chih-Hao Lu)